Rendeiro group

Yimin's paper on a a novel visualization paradigm and implementation of cross-layout visualizations is now published in the journal Genome Biology (doi:10.1186/s13059-024-03469-3).

First published as a preprint in 2024, and open sourced on GitHub it gained some traction in the biology community.

In great part this was due to Yimin's talk and workshop on declarative creation of composable visualization for omics data at the scverse conference in 2024 - thank you to the whole community for the support and encouragement.

Check out the full paper at https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03469-3.

Thank you to the organizers for selecting an abstract from our team for an oral presentation and for starting a Society on such a timely and exciting field. Check out their website at https://spatialbiologysociety.eu/

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Thank you for the invitation to speak and congratulations on the organization of a conference on such a relevant topic!

We had a lot of fun doing an escape room adventure and trying out new food at a spanish tapas restaurant.

To celebrate the start of the LBI-NetMed institute and its new installations we had a huge party!

Thank you to all that attended and became part of the LBI-NetMed family!

A big congratulations and thank you to the organizer team, in particular Christiane Hütter and Annette Tesarek - and Jörg Mensche for putting together this bold idea!

Our study reveals focuses on the structural changes human tissues undergo during aging and how they reflect its physiological state.

By analyzing over 25,000 histopathological images across various tissues from nearly 1,000 individuals, we developed 'tissue clocks' that can estimate biological age based on tissue morphological characteristics. We found that aging manifests differently in various organs, some showing accelerated changes early in life. Conversely, some individuals show markedly more accceleated aging than others, sometimes in a organ-specific manner. Leveraging these tissue-specific and highly physiological readouts of aging, we demonstrate how we can derive the a proxy for tissue-specific, morphologically driven biological age from blood samples and validate them in diseased samples.

This study highlights the intricate relationship between tissue health and biological aging, and could revolutionize the way we assess and understand the biological processes leading to aging-related diseases.

Read the full work here: https://doi.org/10.1101/2024.11.14.618081

Ernesto presented a poster on deep learning profiling of aging cells using histopathological images at the meeting organized by Cold Spring Harbour Asia.

Yimin presented a poster on the microanatomical decoding of breast cancer metastasis, part of our ongoing work funded by the WWTF. Thank you for the support!

The two packages form a new, modular and scalable framework for whole slide image analysis, bringing the interoperability, efficiency, and familiarity of single-cell analysis in scverse: gh.com/RendeiroLab/LazySlide, gh.com/RendeiroLab/WSIData.

It was challenging, but a very worthy experience to organize the 2024 EU-LIFE community meeting which had the theme of artificial intelligence.

Yimin led a work on a framework and tool for an intuitive generalized visualization paradigm for complex datasets. Check if out at BioRxiv!

We have been awarded a grant by the Vienna Science and Technology foundation (WWTF) for a project led by Julianne Winkler and together with Zsuzsanna Bago-Horvath to work on the multiscale discovery of cellular and microanatomical determinants of metastasis. Our great appreciation to the WWTF for supporting us!